APLIKASI METODE OPTIMASI CENTRAL COMPOSITE DESIGN DALAM FORMULASI SEDIAAN GEL NANOPARTIKEL LIPID DENGAN BAHAN AKTIF 4-n-BUTILRESORCINOL

Lipid nanoparticle is one of the dosage forms that have a particle size 1-100 nm. systems aggregation causes an increase in with storage time so carrier needed can reduce aggregation. The lipid system formulated gel preparations add to matrix thereby reducing Central Composite Design (CCD) part experimental design Response Surface Methodology be used determine optimization gelling agents and humectants formulation preparations. aim this study was obtain optimum composition carbopol 940 propylene glycol active ingredient 4-n-butylresorcinol using method Design. This research independent variables, dependent variable, physical properties stability preparation. results were 0.46 grams 9.23 mL determined as point obtained from smallest area CCD method.